Publications

  • Georges R.-N., Ballut L., Aghalari N., Hecquet L., Charmantray F., Doumèche B., Biochemical, Bioinformatic, and Structural Comparisons of Transketolases and Position of Human Transketolase in the Enzyme Evolution. Biochemistry 2024; 63(11): 1460-1473. https://doi.org/10.1021/acs.biochem.3c00714
  • Georges R.-N., Ballut L., Octobre G., Comte A., Hecquet L., Charmantray F., Doumèche B., Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior. Protein Science. 2024; 33(3):e4884. https://doi.org/10.1002/pro.4884

Communications

  • Bastien Doumèche, Jean-Francois Chateaux, Numa-Rainier Georges, Florian Bianco, Nathan Montmailler, Franck Charmantray, Béatrice Leca-Bouvier, Guillaume Octobre, Electrochemical Device for 96-Well Electrochemistry : Amperometry and Electrochemiluminescence, 74th Annual ISE Meeting, Lyon, France, 3rd-8th September 2023. Télécharger ici
  • Bastien Doumèche, Sofiène Abdellaoui, Chloé Aymard, Marjorie Ochs, Guillaume Octobre, Béatrice Leca-Bouvier, Alexandre Noiriel, Christine Mousty, Laurence Hecquet, Franck Charmantray, Florian Bianco, Jean-François Chateaux, Camilla Kärnfelt, Loïc J. Blum, Electrochemical screening as alternative for drug and enzyme discovery. First international symposium on High-Throughput Catalysts Design, 100% Digital Event (France), 14-15th June 2021 (présentation sur cette page).

Posters

  • Georges R.-N., Ballut L., Octobre G., Aghajari N., Hecquet L., Charmantray F., Doumèche B., Transketolases from animals are structurally different from others, Congrès annuel de la SFBBM, Lyon, France, 4th-5th July 2024. Télécharger ici
  • Georges R.-N., Charmantray F., Chateaux J.-F., Doumèche B. New multiplexed electrochemical system for chemical libraries screening, 74th Annual ISE Meeting, Lyon, France, 3rd-8th September 2023. Télécharger ici
  • Chateaux J.-F., Georges R.-N., Bianco F., Doumèche B., A new electrochemical device for multi-purpose screening, 13èmes Journées de la Chimiothèque Nationale – ChemBioFrance, Villeurbanne, France, 29th June 1st July 2022. Télécharger ici
  • Georges R.-N., Charmantray F., Hecquet L., Doumèche B., Electrochemical screening of a chemical library of transketolases inhibitors, XXVIITH International Symposium on Bioelectrochemistry and Bioenergetics, Antwerpen, Belgium, 3th-7th April 2022. Télécharger ici
  • Georges R.-N., Aymard C., Hecquet L., Blum L.J., Charmantray F., Doumèche B., Electrochemical high-throughput screening of transketolase activity, First international symposium on High-Throughput Catalysts Design, 100% Digital Event (France), 14-15th June 2021. Télecharger ici

Pour en savoir plus:

  • Aymard, C., et al., High-Throughput Electrochemical Screening Assay for Free and Immobilized Oxidases: Electrochemiluminescence and Intermittent Pulse Amperometry. Chemelectrochem, 2017, 4(4): p. 957-966. 10.1002/celc.201600647.
  • Charmantray, F., et al., Fluorogenic substrates for the screening assay of transketolase through beta-elimination of umbelliferone-Development, scope and limitations. Journal of Biotechnology, 2010, 145(4): p. 359-366. 10.1016/j.jbiotec.2009.12.022ISTEX.
  • Touisni, N., et al., An efficient amperometric transketolase assay: Towards inhibitor screening. Biosensors & Bioelectronics, 2014, 62: p. 90-96. 10.1016/j.bios.2014.06.019.
  • Halma, M., et al., Thiamine biosensor based on oxidative trapping of enzyme-substrate intermediate. Biosensors & Bioelectronics, 2017, 87: p. 850-857. 10.1016/j.bios.2016.09.049.
  • Abdellaoui, S., et al., Rapid electrochemical screening of NAD-dependent dehydrogenases in a 96-well format. Chemical Communications, 2013. 49(51): p. 5781-5783. 10.1039/c3cc42065e.
  • Abdellaoui, S., et al., A 96-Well Electrochemical Method for the Screening of Enzymatic Activities. Analytical Chemistry, 2013, 85(7): p. 3690-3697. 10.1021/ac303777r.
  • Simon, G., et al., Synthesis of Specially Designed Probes to Broaden Transketolase Scope. Chemcatchem, 2013, 5(3): p. 784-795. 10.1002/cctc.201200479ISTEX.
  • Legeret, B., et al., Substrate cycling based fluorometric assay for dihydroxyacetone phosphate. Journal of Molecular Catalysis B-Enzymatic, 2015, 114: p. 13-18. 10.1016/j.molcatb.2014.07.005.